Scientific Research Publications

We are committed to advancing the field of fertility through scientific research. Below is a list of the most recent publications authored by our physicians.

2011

Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery.

Publication: Reproductive Biology & Endocrinology
Author: Weghofer A, Dietrich W, Ortner I, Bieglmayer C, Barad D, Gleicher N.
Date: 2011
Page #: 9(1):98

To the Editor, on Sunkara et al.

Publication: Human Reproduction
Author: Gleicher N, Weghofer A, Barad DH.
Date: 2011
Page #: E-letter [online only]

Cutting edge assessment of the impact of autoimmunity on female reproductive success

Publication: Journal of Autoimmunity
Author: Gleicher N, Weghofer A, Barad DH.
Date: 2011
Page #: In Press

Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR).

Publication: Reproductive Biology & Endocrinology
Author: Gleicher N, Barad DH.
Date:  2011
Page #: 9:67

Gestational Dermatosis Shortly after Implantation Associated with Parental Class II HLA Compatibility and Maternal Immune Activation: Preliminary Report of a Prospective Case Series.

Publication: Dermatology

Author: Gleicher N, Barad DH.
Date: 2011
Page #: DOI: 10.1159/000327377

Association of FMR1 Genotypes with In Vitro Fertilization (IVF) Outcomes Based on Ethnicity/Race.

Publication:  PLoS One
Author:  Gleicher N, Weghofer A, Lee I, Barad DH.
Date: 2011
Page #: 6(4): e18781.
Summary: IVF success rates have been widely reported to differ in different race/ethnic groups. For example, the rates are lower in infertility patients of African origin. New research from CHR suggests that this may be due to differences in genetic predisposition to autoimmunity, evidenced by a specific sub-genotype of the FRM1 gene.

Dehydroepiandrosterone

Publication:  How to Improve Your ART Success Rates: An Evidence-Based Review of Adjuncts to IVF
Author: Gleicher N, Barad DH.
Date:  2011
Page #: 93-98.

Summary: CHR revolutionized the treatment of infertility in women with diminished ovarian reserve by introducing dehydroepiandrosterone (DHEA) into fertility practice. CHR physicians were invited to contribute a chapter on DHEA use in a comprehensive book on recent developments in IVF modalities.

Utility of age-specific serum anti-Müllerian hormone concentrations.

Publication:  RBMOnline
Author:  Barad DH, Weghofer A, Gleicher N.
Date: 2011
Page #:  22;284-291.
Summary: Age-specific levels of anti-Müllerian hormone (AMH) better reflects ovarian reserve than AMH levels that are not age-specific. Compared to age-specific FSH, age-specific AMH defines risk of diminished ovarian reserve or abnormally high oocyte yields (ovarian hyperstimulation syndrome), and therefore may be a particularly useful ovarian reserve test in younger women, in whom diminished ovarian reserve is most frequently overlooked, and who are at highest risk for ovarian hyperstimulation syndrome.

Defining ovarian reserve to better understand ovarian aging.

Publication:  Reprod Biol Endocrinol
Author:  Gleicher N, Weghofer A, Barad DH.
Date:  2011
Page #: 9:23
Summary: This review article explores the concept of functional ovarian reserve, focusing on the entire pool of follicles available for recruitment and maturation. By looking beyond the gonadotropin-sensitive phase of folliculogenesis (on which most research has focused so far), we may be able to improve ovarian stimulation protocols for women with diminished ovarian reserve.

Successful treatment of unresponsive thin endometrium

Publication: Fertility & Sterility
Author: Gleicher N, Weghofer A, Barad DH.
Date:  2011
Page #: 95(6):2123.e13-7 [epub ahead of print]
Summary: Some IVF patients do not develop adequate endometrium (uterine lining) prior to embryo transfer, even with treatment. In this case study, four patients at two different IVF centers improved their emdometrium after receiving intrauterine perfusions of G-CSF, and eventually got pregnant. This study suggests that G-CSF may be a promising tool to improve implantation. Read the details.

2010

Do chromosomally abnormal pregnancies really preclude autoimmune etiologies of spontaneous miscarriages?

Publication:  Autoimmunity Reviews
Author: Gleicher N, Weghofer A, Barad DH.
Date: 2010
Page #: Epub ahead of print.
Summary:  Current dogma in both rheumatology and obstetrics/gynecology holds that evidence of aneuploidy in miscarriages rules out autoimmune etiology. However, literature review suggests that maternal autoimmunity itself may increase the risk toward aneuploidy in abortuses and offspring.

FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.

Publication:  PLoS One
Author: Gleicher N, Weghofer A, Lee IH, Barad DH.
Date: 2010
Page #: 10.1371
Summary: A specific genotype of FMR1 gene appears to be associated with a form of PCO with autoimmunity. This specific genotype is also associated with an almost 50% reduction in pregnancy chances in IVF, compared to the normal genotype.

Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS).

Publication:  Reproductive Biology and Endocrinology
Author: Gleicher N, Weghofer A, Barad DH.
Date: 2010
Page #: 10;8:140.
Summary: A study employing Preimplantation Genetic Screening (PGS) reveals that dehydroepiandrosterone (DHEA) supplementation before and during an IVF treatment can reduce embryo’s chromosomal abnormalities by about 22%. This improvement in embryo quality after DHEA supplementation leads to lower rate of miscarriages after IVF.

Does fetal sex influence the risk of preterm delivery in dichorionic twin pregnancies after spontaneous conception?

Publication: Twin Res Hum Genet
Author:  Klein K, Worda C, Stammler-Safar M, Husslein P, Gleicher N, Weghofer A.
Date:  2010
Page #: 13:495-500.

The FMR1 gene as regulator of ovarian recruitment and ovarian reserve.

Publication: Obstetrical and Gynecological Survey
Author: Gleicher N, Barad DH
Date: 2010
Page #: 65(8);523-530.

Further comments on the Suleman case.

Publication: Expert Reviews of Obstetrics & Gynecology
Author: Gleicher N, Barad D.
Date: 2010
Page #: 5;501-502.

Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation.

Publication: RBMOnline
Author: Gleicher N, Weghofer A, Barad D.
Date: 2010
Page #: 21;360-365.

Misplaced obsession with prospectively randomized studies.

Publication: RBMOnline
Author: Gleicher N, Barad D.
Date: 2010
Page #: 21:440-3.

Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live-birth chances in women with severely diminished ovarian reserve

Publication:  Fertility & Sterility
Author: Gleicher N, Weghofer A, Barad D.
Date: 2010
Page #: 94: 2824-7.

Can egg donor selection be improved? – a pilot study.

Publication:Reprod Biol Endocrinol
Author: Gleicher N, Weghofer A, Barad D.
Date: 2010
Page #: 8:76.

Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation.

Publication: RBMOnline
Author: Gleicher N, Weghofer A, Barad D.
Date: 2010
Page #: Epub ahead of print.

For a complete archive of publications please visit our main Scientific Publications site.

Last Updated: August 23, 2011

Tags: Scientific Research, Publications